vocimagene amiretrorepvec

{
  "id": "MLC-T-ONC-017523",
  "term": "vocimagene amiretrorepvec",
  "field": "Oncology and biomedicine",
  "definition": "A replication competent retroviral vector, derived from the Moloney murine leukemia virus (MoMLV), encoding a modified form of the yeast suicide gene cytosine deaminase (CD) (Toca 511) used as an antineoplastic adjuvant. Upon transcranial injection, vocimagene amiretrorepvec preferentially enters and transfects tumor cells, and expresses cytosine deaminase, an enzyme that catalyzes the intracellular conversion of the prodrug flucytosine (5-FC) into the antineoplastic agent 5-fluorouracil (5-FU). After administration of 5-FC, the tumor can be eradicated upon activation of 5-FU.",
  "synonyms": [
    "retroviral virus vector encoding cytosine deaminase"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/vocimagene-amiretrorepvec/"
}