E. coli CD-expressing genetically modified neural stem cells

{
  "id": "MLC-T-ONC-013194",
  "term": "E. coli CD-expressing genetically modified neural stem cells",
  "field": "Oncology and biomedicine",
  "definition": "Genetically-modified neural stem cells (NSCs) transfected with the Escherichia coli (E. coli) suicidal gene cytosine deaminase (CD), with potential antineoplastic adjuvant activity. Upon intracerebral injection, E. coli CD-expressing genetically modified NSCs express the E. coli cytosine deaminase, an enzyme that catalyzes the intracellular conversion of the nontoxic prodrug 5-fluorocytosine (5-FC) into the cytotoxic 5-fluorouracil (5-FU). Co-administration of this agent with 5-FC and upon local activation of 5-FU in the brain tumor, 5-FU disrupts DNA synthesis in tumor cells thereby impeding cellular proliferation with minimal systemic exposure and toxicity.",
  "abbreviation": "HB1.F3.CD neural stem cells",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/e-coli-cd-expressing-genetically-modified-neural-stem-cells/"
}