Carboxylesterase-expressing allogeneic neural stem cells

{
  "id": "MLC-T-ONC-012299",
  "term": "Carboxylesterase-expressing allogeneic neural stem cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic neural stem cells (NSC), derived from a human fetal cell line, that are adenovirally-transduced to express a modified form of the human enzyme carboxylesterase (CE) hCE1m6, with potential adjuvant activity. Upon intracranial administration, NSCs localize to tumor sites, due to their tumor-trophic nature, and transiently express hCE1m6. Intravenous co-administration of the prodrug irinotecan allows for the selective conversion by hCE1m6 to its active metabolite and topoisomerase I inhibitor, SN-38, in the vicinity of tumor sites. This leads to a local anti-neoplastic effect and causes reduced toxicity and increased therapeutic efficacy of irinotecan. Since NSCs freely cross the blood-brain barrier, these cells can also be intravenously administered to target brain tumor cells. hCE1m6 shows increased activity as compared to unmodified human CE.",
  "abbreviation": "hCE1m6-NSC",
  "synonyms": [
    "CE-secreting allogeneic NSCs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carboxylesterase-expressing-allogeneic-neural-stem-cells/"
}