neural stem cells-expressing CRAd-S-pk7

{
  "id": "MLC-T-ONC-015493",
  "term": "neural stem cells-expressing CRAd-S-pk7",
  "field": "Oncology and biomedicine",
  "definition": "Neural stem cells (NSCs) that are transfected with the gliomatropic oncolytic adenovirus (OV) CRAd-S-pk7, a conditionally replicative oncolytic adenoviral (CRAd) vector that contains the tumor-specific survivin promoter (S) and a fiber protein polylysine modification (pk7), with potential antineoplastic activity. Upon intracerebral administration of NSC loaded with CRAd-S-pk7, the NSCs preferentially migrate towards tumor cells, and the polylysine moiety of the modified fiber protein expressed by the viral vector specifically targets and binds to tumor-specific heparan sulfate proteoglycans. Subsequently, the virus can infect the tumor cells and viral replication is initiated because E1 gene expression is controlled by the tumor-specific promoter for survivin. This results in the specific lysis of the glioma cells. The pk7 fiber modification and the survivin promoter enable tumor-specific infectivity, and transcriptional targeting and preferential replication in glioma cells, while sparing the surrounding normal brain parenchyma. The pK7 is comprised of a heparan sulfate binding domain incorporated into the fiber protein of the adenovirus.j",
  "synonyms": [
    "NSC-CRAd-S-pk7",
    "NSC-CRAd-Survivin-pk7",
    "NSC-CRAd-S-pk7 virotherapeutic",
    "CRAd-S-pk7 loaded NSCs",
    "NSCs loaded with CRAd-S-pk7"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/neural-stem-cells-expressing-crad-s-pk7/"
}