vopratelimab

{
  "id": "MLC-T-ONC-017534",
  "term": "vopratelimab",
  "field": "Oncology and biomedicine",
  "definition": "An agonistic humanized monoclonal antibody that recognizes inducible T-cell co-stimulator (ICOS; CD278), with potential antineoplastic activity. Upon administration, vopratelimab targets and binds to ICOS expressed on certain T cells. This stimulates ICOS-mediated signaling, induces proliferation of ICOS-positive T cells, enhances cytotoxic T-lymphocyte (CTL) survival and augments the CTL-mediated immune response against tumor cells. ICOS, a T-cell specific, CD28-superfamily co-stimulatory molecule and immune checkpoint protein, is normally expressed on certain activated T cells and plays a key role in the proliferation and activation of T cells.",
  "synonyms": [
    "anti-ICOS agonist MAb JTX-2011",
    "ICOS agonist monoclonal antibody JTX-2011"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/vopratelimab/"
}