anti-ICOS agonist monoclonal antibody BMS-986226

{
  "id": "MLC-T-ONC-010803",
  "term": "anti-ICOS agonist monoclonal antibody BMS-986226",
  "field": "Oncology and biomedicine",
  "definition": "An agonistic monoclonal antibody that recognizes inducible T-cell co-stimulator (ICOS; CD278), with potential immunomodulating and antineoplastic activities. Upon administration, anti-ICOS agonist monoclonal antibody BMS-986226 targets and binds to ICOS expressed on certain T cells. This stimulates ICOS-mediated signaling, induces proliferation of ICOS-positive T cells, enhances cytotoxic T lymphocyte (CTL) survival and augments the CTL-mediated immune response against tumor cells. ICOS, a T-cell-specific, CD28-superfamily co-stimulatory molecule and immune checkpoint protein, is normally expressed on certain activated T cells and plays a key role in the proliferation and activation of T cells.",
  "synonyms": [
    "anti-ICOS BMS-986226",
    "anti-inducible T-cell co-stimulator BMS-986226"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-icos-agonist-monoclonal-antibody-bms-986226/"
}