Otic compositions for the treatment of infections of the internal and external ear in mammals

{
  "publication_number": "US2012003174A1",
  "country": "US",
  "kind": "A1",
  "title": "Otic compositions for the treatment of infections of the internal and external ear in mammals",
  "abstract": "Disclosed herein compositions including povidone-iodine (PVP-I) useful in the treatment of acute and chronic bacterial, viral and fungal infections of the internal, middle and external ear of mammals, including humans.",
  "claims": [
    "1. A method of treating a mammal having an otic infection, the method comprising contacting the ear of the mammal with a composition comprising: a. povidone iodine (PVP-I) at a concentration of 0.01%-5.0%; and b. a steroid at a concentration of 0.01%-2.0%. 2. The method of claim 1, wherein the otic condition is at least one member selected from the group consisting of bacterial otitis externa, malignant otitis, fungal otitis externa, otomycosis, otitis media, and otitis interna. 3. The method of claim 1, wherein the steroid is selected from the group consisting of a dexamethasone, a fluromethalone, a lotoprendol, a medrysone, a prednisolone, a difluprednate, a rimexolone, and a hydrocortisone. 4. The method of claim 1, wherein the steroid is dexamethasone or a salt thereof. 5. The method of claim 1, wherein the composition is contacted to the ear in the form of an ear drop or a zinc acetate composition. 6. The method of claim 1, wherein the PVP-I is present at a concentration of 1.0%-3.0%. 7. The method of claim 1, wherein the PVP-I is present at a concentration of 2.0%. 8. The method of claim 1, wherein the steroid is present at a concentration of 0.05%-0.1%. 9. The method of claim 1, wherein the steroid is present at a concentration of 0.1%."
  ],
  "description_excerpt": "Otitis externa (external ear infection) is an inflammation of the outer ear and ear canal. It is a common cause of earache in humans and a common problem in dogs, cats and other mammals. It also occurs in many other species. This disorder involves inflammation of the skin of the ear canal. The inflammation can be caused by active fungal, viral or bacterial organisms. The ear canal skin often swells and may become painful and tender to touch.\n\nOtitis media (middle ear infection) occurs in the area between the ear drum and the inner ear, including the Eustachian tube. Otitis media is very common in childhood, with the average toddler experiencing two to three episodes a year, almost always accompanied by a viral upper respiratory infection (URI), mostly the common cold. The rhinoviruses and adenoviruses that cause many common cold symptoms cause swelling and congestion in the inner ear which can permanently damage middle ear structures. Otitis media is also frequently caused by a variety of bacteria and other viruses.\n\nFurthermore, ear infection (particularly in children) is one of the many diseases that have become hard to treat with traditional antibiotic drugs because of antibiotic resistant bacteria and antibiotic-resistant microorganisms. Most cases of otitis media, for example, are caused by one of several major pathogens, Streptococcus pneumonia, Haemophilus nfluenza, Moraxella catarrhalia, Staphylococcus aureus, Staphylococcus epidermidis, or Pseudomonas aeruginosa. There is thus an urgent need to develop new, non-antibiotic approaches to prevent and manage these diseases.",
  "cpc": [
    "A61K 31/79",
    "A61K 2121/00",
    "A61K 31/573",
    "A61K 9/0031",
    "A61K 9/0046",
    "A61K 9/06",
    "A61P 27/00",
    "A61P 27/06",
    "A61P 27/16",
    "A61P 29/00",
    "A61P 31/02",
    "A61P 31/04",
    "A61P 31/10",
    "A61P 43/00"
  ],
  "ipc": [
    "A61K 31/79",
    "A61P 31/04",
    "A61P 31/10"
  ],
  "assignees": [
    "Foresight Biotherapeutics Inc"
  ],
  "inventors": [
    "Joseph A. Capriotti",
    "Bo Liang",
    "C. Michael Samson",
    "Jason Stein",
    "Michael Weiser"
  ],
  "filing_date": "2011-09-16",
  "publication_date": "2012-01-05",
  "priority_date": "2008-01-28",
  "application_number": "US-201113234978-A",
  "family_id": "44834943",
  "cited_by_count": 5
}