Microalgal polysaccharide compositions

{
  "publication_number": "US10278912B2",
  "country": "US",
  "kind": "B2",
  "title": "Microalgal polysaccharide compositions",
  "abstract": "Provided herein are microalgal polysaccharide compositions and. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel microalgal compositions useful for improving the health and appearance of skin. The invention also includes insoluble polysaccharide particles for application to human skin.",
  "claims": [
    "1. A product suitable for topical administration, comprising: isolated exopolysaccharide from microalgae of the species Parachlorella kessleri or Parachlorella beijerincki, wherein the monosaccharide content of the exopolysaccharide comprises 15-55 mole percent rhamnose, 3-30 mole percent xylose, 1-25 mole percent mannose, 1-45 mole percent galactose, 0.5-10 mole percent glucose, and 0.1-15 mole percent glucuronic acid, and wherein the exopolysaccharide is prepared by drying and annealing at a temperature of between about 125° C. and about 155° C. so as to form particles that are partially soluble in water and increase in volume at least two-fold upon contact with water compared to the anhydrous volume of the exopolysaccharide particles; and at least one other cosmetic ingredient.",
    "2. The product of claim 1, wherein the exopolysaccharide has been milled to provide exopolysaccharide particles having an average particle size of between about 400 microns and about 0.1 microns.",
    "3. The product of claim 1, wherein the average particle size of the exopolysaccharide particles is between about 50 microns and about 200 microns.",
    "4. The product of claim 2, wherein the exopolysaccharide particles resuspended in water have a viscosity of between about 500 cP and about 1000 cP.",
    "5. The product of claim 1, wherein the at least one other cosmetic ingredient is selected from the group consisting of beta carotene, lutein, astaxanthin, vitamin C, vitamin E, vitamin A, coenzyme Q10, a peptide, an acylated peptide, oil soluble a-hydroxy acid, an alkyl lactate, and salicylic acid.",
    "6. The product of claim 1, wherein the at least one other cosmetic ingredient is selected from the group consisting of water, sodium hyaluronate, betaine, trisodium EDTA, glycerin, blutylene glycol, amphisol K, shea butter, macadamian oil, isocetyl stearate, olive oil, PEG 150 distearate, grancil VX401, glyceryl monostearate, polyethylene, granpowder USQ, grancil PSQ, diocide and fragrance.",
    "7. The product of claim 1 that is a cream, lotion, serum, gel, solution, spray or ointment.",
    "8. The product of claim 1, wherein the exopolysaccharide particles are from Parachlorella kessleri.",
    "9. A product suitable for topical administration, comprising: isolated exopolysaccharide from microalgae of the species Chorella sorokiniana, wherein the monosaccharide content of the exopolysaccharide comprises 15-55 mole percent rhamnose, 3-30 mole percent xylose, 1-25 mole percent mannose, 1-45 mole percent galactose, 0.5-10 mole percent glucose, and 0.1-15 mole percent glucuronic acid, and wherein the exopolysaccharide is prepared by drying and annealing at a temperature of between about 125° C. and about 155° C. so as to form particles that are partially soluble in water and increase in volume at least two-fold upon contact with water compared to the anhydrous volume of the exopolysaccharide particles; and at least one other cosmetic ingredient.",
    "10. The product of claim 9, wherein the exopolysaccharide has been milled to provide exopolysaccharide particles having an average particle size of between about 400 microns and about 0.1 microns.",
    "11. The product of claim 9, wherein the average particle size of the exopolysaccharide particles is between about 50 microns and about 200 microns.",
    "12. The product of claim 10, wherein the exopolysaccharide particles resuspended in water have a viscosity of between about 500 cP and about 1000 cP.",
    "13. The product of claim 9, wherein the at least one other cosmetic ingredient is selected from the group consisting of beta carotene, lutein, astaxanthin, vitamin C, vitamin E, vitamin A, coenzyme Q10, a peptide, an acylated peptide, oil soluble a-hydroxy acid, an alkyl lactate, and salicylic acid.",
    "14. The product of claim 9, wherein the at least one other cosmetic ingredient is selected from the group consisting of water, sodium hyaluronate, betaine, trisodium EDTA, glycerin, blutylene glycol, amphisol K, shea butter, macadamian oil, isocetyl stearate, olive oil, PEG 150 distearate, grancil VX401, glyceryl monostearate, polyethylene, granpowder USQ, gransil PSQ, diocide and fragrance.",
    "15. The product of claim 9 that is a cream, lotion, serum, gel, solution, spray or ointment.",
    "16. The product of claim 1, wherein the exopolysaccharide particles are from Parachlorella beijerinckii.",
    "17. The product suitable for topical administration of claim 1, wherein the microalgae species have at least 95% 23 S rRNA genomic sequence identity to SEQ ID NO:3.",
    "18. The product suitable for topical administration of claim 9, wherein the microalgae species have at least 95% 23 S rRNA genomic sequence identity to SEQ ID NO: 4."
  ],
  "description_excerpt": "The invention resides in the fields of health and beauty, cosmetic ingredients and aquaculture.\n\nCarbohydrates have the general molecular formula CH 2 O, and thus were once thought to represent “hydrated carbon”. However, the arrangement of atoms in carbohydrates has little to do with water molecules. Starch and cellulose are two common carbohydrates. Both are macromolecules with molecular weights in the hundreds of thousands. Both are polymers; that is, each is built from repeating units, monomers, much as a chain is built from its links.\n\nThree common sugars share the same molecular formula: C 6 H 12 O 6. Because of their six carbon atoms, each is a hexose. Glucose is the immediate source of energy for cellular respiration. Galactose is a sugar in milk. Fructose is a sugar found in honey. Although all three share the same molecular formula (C 6 H 12 O 6), the arrangement of atoms differs in each case. Substances such as these three, which have identical molecular formulas but different structural formulas, are known as structural isomers. Glucose, galactose, and fructose are “single” sugars or monosaccharides.\n\nTwo monosaccharides can be linked together to form a “double” sugar or disaccharide. Three common disaccharides are sucrose, common table sugar (glucose+fructose); lactose, the major sugar in milk (glucose+galactose); and maltose, the product of starch digestion (glucose+glucose). Although the process of linking the two monomers is complex, the end result in each case is the loss of a hydrogen atom (H) from one of the monosaccharides and a hydroxyl group (OH) from the other.",
  "cpc": [
    "A61K 8/73",
    "A61K 2800/412",
    "A61K 2800/654",
    "A61K 8/0241",
    "A61K 8/9706",
    "A61K 8/9722",
    "A61K 8/9728",
    "A61K 8/9789",
    "A61K 8/9794",
    "A61Q 19/08",
    "C08B 37/0003",
    "C08B 37/0036",
    "C08B 37/006",
    "C08L 5/00",
    "C12P 19/04",
    "Y10T 428/2982"
  ],
  "ipc": [
    "A61K 8/02",
    "A61K 8/73",
    "C08B 37/00",
    "C12P 19/04",
    "A61K 31/715",
    "A61K 8/9706",
    "A61Q 19/08",
    "C08L 5/00"
  ],
  "assignees": [
    "Algenist Holdings Inc"
  ],
  "inventors": [
    "Anna Coragliotti",
    "Scott Franklin",
    "Anthony G. Day",
    "Stephen M. Decker"
  ],
  "filing_date": "2014-11-25",
  "publication_date": "2019-05-07",
  "grant_date": "2019-05-07",
  "priority_date": "2008-10-14",
  "application_number": "US-201414553138-A",
  "family_id": "46601049",
  "cited_by_count": 2,
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