Compositions for improving the health and appearance of skin

{
  "publication_number": "US10231907B2",
  "country": "US",
  "kind": "B2",
  "title": "Compositions for improving the health and appearance of skin",
  "abstract": "Provided herein are microalgal skin care compositions and methods of improving the health and appearance of skin. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel decolorized microalgal compositions useful for improving the health and appearance of skin. The invention also includes insoluble polysaccharide particles for application to human skin.",
  "claims": [
    "1. A gel, lotion, cream or ointment composition suitable for topical administration comprising microalgal exopolysaccharide particles, the exopolysaccharide produced by microalgae of the genus Parachlorella, wherein the exopolysaccharide particles are made by: culturing microalgae cells in a culture medium so that exopolysaccharide is secreted by the microalgal cells into the culture medium; separating the exopolysaccharide from the microalgal cells to create a purified exopolysaccharide; heating, in two parts, the purified exopolysaccharide, the first part being performed at a temperature in the range of 60° C. to 100° C. and the second part being performed at a temperature range of 148° C.-160° C. so as to render it partially insoluble in water, and so that it forms a polysaccharide gel in water; and generating particles having an average size of between 0.1 and 400 microns from the heated exopolysaccharide, wherein the particles increase in volume on contact with water by at least 100% compared to their anhydrous volume; and the particles increase in volume for at least 4 hours, and wherein the composition when applied to mammalian skin reduces the presence of crow's feet fine lines/wrinkles, increases skin elasticity, increases skin moisture, or decreases transepidermal water loss.",
    "2. The composition of claim 1, wherein the particles increase in volume on contact with water by at least 200% compared to their anhydrous volume.",
    "3. The composition of claim 1, wherein the composition further comprises between 50-97% ethylhexyl palmitate, 1-5% silica dimethyl silylate, 0.1-3% butylene glycol, and 0.1-3% of one or more preservative selected from the group consisting of diocide, dowicil 200, and methyl paraben.",
    "4. The composition of claim 1, wherein the particles are generated by milling the heated purified exopolysaccharide.",
    "5. The composition of claim 1, further comprising at least one ingredient selected from the group consisting of beta carotene, lutein, astaxanthin, vitamin C, vitamin E, vitamin A, and coenzyme Q10, a peptide, an acetylated peptide, oil soluble a-hydroxy acid, an alkyl lactate, and salicylic acid.",
    "6. A gel, lotion, cream or ointment composition suitable for topical administration comprising microalgal exopolysaccharide particles, the exopolysaccharide produced by microalgae of the genus Parachlorella, wherein the exopolysaccharide particles are made by: culturing microalgae cells in a culture medium so that exopolysaccharide is secreted by the microalgal cells into the culture medium; separating the exopolysaccharide from the microalgal cells to create a purified exopolysaccharide; heating, in two parts, the purified exopolysaccharide, the first part being performed at a temperature in the range of 60° C. to 100° C. and the second part being performed at a temperature of 148° C.-160° C. so as to render it partially insoluble in water, and so that it forms a polysaccharide gel in water; and generating particles having an average size of between 0.1 and 400 microns from the heated exopolysaccharide, wherein the particles increase in volume on contact with water by at least 100% compared to their anhydrous volume; and the particles increase in volume for at least 4 hours, and wherein the composition when applied to mammalian skin cells stimulates an anti-inflammatory response in the mammalian cell, the anti-inflammatory response selected from the group consisting of reducing lymphocyte proliferation, reducing gamma interferon production, reducing interleukin la production, and reducing erythema.",
    "7. The composition of claim 6, wherein the particles increase in volume on contact with water by at least 200% compared to their anhydrous volume.",
    "8. The composition of claim 6, wherein the composition further comprises between 50-97% ethylhexyl palmitate, 1-5% silica dimethyl silylate, 0.1-3% butylene glycol, and 0.1-3% of one or more preservative selected from the group consisting of diocide, dowicil 200, and methyl paraben.",
    "9. The composition of claim 6, wherein the particles are generated by milling the heated purified exopolysaccharide.",
    "10. The composition of claim 6, further comprising at least one ingredient selected from the group consisting of beta carotene, lutein, astaxanthin, vitamin C, vitamin E, vitamin A, and coenzyme Q10, a peptide, an acetylated peptide, oil soluble a-hydroxy acid, an alkyl lactate, and salicylic acid.",
    "11. A gel, lotion, cream or ointment composition suitable for topical administration comprising microalgal exopolysaccharide particles, the exopolysaccharide produced by microalgae of the genus Parachlorella, wherein the exopolysaccharide particles are made by: culturing microalgae cells in a culture medium so that exopolysaccharide is secreted by the microalgal cells into the culture medium; separating the exopolysaccharide from the microalgal cells to create a purified exopolysaccharide; heating, in two parts, the purified exopolysaccharide, the first part being performed at a temperature in the range of 60° C. to 100° C. and the second part being performed at a temperature of 148° C.-160° C. so as to render it partially insoluble in water, and so that it forms a polysaccharide gel in water; and generating particles having an average size of between 0.1 and 400 microns from the heated exopolysaccharide, wherein the particles increase in volume on contact with water by at least 100% compared to their anhydrous volume; and the particles increase in volume for at least 4 hours, and wherein the composition when applied to mammalian skin cells stimulates the synthesis of procollagen and/or elastin in the mammalian cell.",
    "12. The composition of claim 11, wherein the particles increase in volume on contact with water by at least 200% compared to their anhydrous volume.",
    "13. The composition of claim 11, wherein the composition further comprises between 50-97% ethylhexyl palmitate, 1-5% silica dimethyl silylate, 0.1-3% butylene glycol, and 0.1-3% of one or more preservative selected from the group consisting of diocide, dowicil 200, and methyl paraben.",
    "14. The composition of claim 11, wherein the particles are generated by milling the heated purified exopolysaccharide.",
    "15. The composition of claim 11, further comprising at least one ingredient selected from the group consisting of beta carotene, lutein, astaxanthin, vitamin C, vitamin E, vitamin A, and coenzyme Q10, a peptide, an acetylated peptide, oil soluble a-hydroxy acid, an alkyl lactate, and salicylic acid."
  ],
  "cpc": [
    "A61K 8/0241",
    "A61K 8/73",
    "A61K 8/9706",
    "A61K 8/9717",
    "A61K 8/9722",
    "A61P 17/00",
    "A61Q 19/08",
    "C08B 37/0003",
    "C12N 1/125",
    "C12P 19/04",
    "C12R 1/89",
    "C12R 2001/89"
  ],
  "assignees": [
    "ALGENIST HOLDINGS INC"
  ],
  "filing_date": "2015-06-26",
  "publication_date": "2019-03-19",
  "grant_date": "2019-03-19",
  "priority_date": "2006-01-19",
  "application_number": "US-201514751527-A",
  "family_id": "40432501",
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