Agent for the care of skin

{
  "publication_number": "US3991184A",
  "country": "US",
  "kind": "A",
  "title": "Agent for the care of skin",
  "abstract": "For the care of skin there is contemplated the use of untreated, soluble collagen having an unchanged substantially non-crosslinked collagen structure and obtained by the direct extraction from the connective tissue of skin.",
  "claims": [
    "1. An agent for the care of the skin in the form of a cosmetic preparation, said agent comprising a content of 3-20 per cent of native soluble collagen having unchanged native, extensively non-crosslinked structure, said collagen being obtained from skin selected from the group consisting of young and embryonal animal skin by extraction in an aqueous acid in a pH range between 3.5 and 4.5 with an organic acid selected from the group consisting of lactic acid, acetic acid and citric acid and salts thereof selected from the group consisting of sodium salts, potassium salts and tri-ethanol amine salts and at a temperature of 4°-10° C.",
    "2. An agent as claimed in claim 1 wherein the collagen is calfskin collagen.",
    "3. An agent as claimed in claim 1 wherein the acid is acetic acid and the salt potassium acetate, the ratio of acid to salt being 5:3.",
    "4. An agent as claimed in claim 1 wherein the acid is lactic acid and the salt triethanolactate, the ratio of acid to salt being 2:3.",
    "5. A method of preparing an agent for increasing the resilience, water absorptivity and swelling capability of skin, said method comprising forming a composition of a carrier and 3-20% of untreated soluble collagen having an unchanged substantially non-crosslinked collagen structure, said collagen being obtained from skin selected from the group consisting of young and embryonal animal skin by extraction from the connective tissue in an acid aqueous medium in a pH range between 3.5 and 4.5 at a temperature of 4°-10° C with at least one organic acid selected from the group consisting of lactic, acetic and citric acid and a salt thereof.",
    "6. A method as claimed in claim 5 wherein said salt is sodium, potassium or tri-ethanol amine salts of the acids.",
    "7. A method as claimed in claim 5 wherein the acid is acetic acid and the salt potassium acetate, the ratio of acid to salt being 5:3.",
    "8. A method as claimed in claim 5 wherein the acid is lactic acid and the salt triethanolactate, the ratio of acid to salt being 2:3."
  ],
  "description_excerpt": "This Application is a continuation of copending application Ser. No. 403,922 filed Oct. 5, 1973, which in turn is a continuation-in-part of application Ser. No. 213,219, filed Dec. 28, 1971 and now abandoned.\n\na. Field of the Invention\n\nThe invention relates to agents for the care of the skin which are distinguished by proven efficacy for their purpose.\n\nB. Prior Art\n\nIn cosmetology there are employed finished products or active substances whose purpose is to produce a revitalizing or rejuvenating effect on the skin. The terms \"revitalizing\" or \"rejuvenating\" are used generally and the contention that a revitalizing effect is achieved is generally not supported by reproducible, pharmacological proof.\n\nIt is known from gerontological research (Bjorksten) that the process of aging of the skin takes place mainly at the connective tissue of the cutis. This corium (85% of the skin thickness located under the epidermis) consists substantially of three-dimensionally intertwined collagenous fibres the chemical units of which are mainly monoamino acids. In the useful fibers, there is principally soluble collagen. In aging skin, the soluble collagen becomes insoluble, inelastic and rigid and is accompanied by the formation of intermolecular and interamolecular crosslinkings. As the skin ages the proportion of insoluble collagen increases, at the expense of the soluble collagen; the aging skin loses its resilience and therewith its water absorptivity and swelling capability.",
  "cpc": [
    "A61K 8/65",
    "A61K 38/00",
    "A61Q 19/00",
    "A61Q 19/08",
    "C07K 14/78"
  ],
  "ipc": [
    "A61K 8/65",
    "A61Q 19/00",
    "C07K 14/78"
  ],
  "inventors": [
    "Martin Kludas",
    "Gunter Borchert"
  ],
  "filing_date": "1974-12-27",
  "publication_date": "1976-11-09",
  "grant_date": "1976-11-09",
  "priority_date": "1973-10-05",
  "application_number": "US-53689374-A",
  "family_id": "27018450",
  "cited_by_count": 119,
  "citations": [
    "GB1205609A"
  ]
}