Surgical method and composition therefor

{
  "publication_number": "US6261582B1",
  "country": "US",
  "kind": "B1",
  "title": "Surgical method and composition therefor",
  "abstract": "Administration of a morphine-based analgesic paste directly to the epidural space during lumbar decompressive surgery significantly improves post-operative pain control, reduces prescribed analgesic consumption, and improves overall health perception for a period of up to 6 weeks following surgery. In a series of 60 patients no treatment related complications attributable to the paste were observed. This post-operative pain control strategy may provide a new gold-standard of care patients undergoing lumbar disectomy or laminectomy.",
  "claims": [
    "1. A medicinal paste for use in a surgical procedure performed on a mammal, including a human, to reduce pain, which comprises; an analgesic; and a microfibrillar collagen.",
    "2. The paste of claim 1 wherein the analgesic is selected from the group consisting of morphine, fentanyl, demerol and a combination thereof.",
    "3. The paste of claim 2 wherein the analgesic selected is morphine.",
    "4. The paste of claim 1 which further comprises an effective amount for anti-inflammatory activity of an anti-inflammatory agent.",
    "5. The paste of claim 4 wherein the anti-inflammatory agent is a steroidal compound.",
    "6. The paste of claim 5 wherein the agent is methylprednisolone acetate.",
    "7. The paste of claim 5 which further comprises a portion of amino caproic acid.",
    "8. The paste of claim 1 wherein the proportion of collagen is in the range of 100 to 1000 mg and the proportion of analgesic is in the range of from 10 to 500 mg.",
    "9. A method of performing surgery on a mammal, including a human, which comprises; making an incision which exposes nerves; and applying an effective amount of a paste of claim 1 to at least some of the exposed nerves so as to provide pain relief to the mammal.",
    "10. The method of claim 9 which further comprises closing the incision so as to secure the paste in place to provide prolonged analgesic relief.",
    "11. The method of claim 10 wherein the surgical procedure is a disectomy or a laminectomy.",
    "12. The method of claim 10 wherein the procedure is a treatment for lumbar stenosis."
  ],
  "description_excerpt": "This application claims priority of Provisional U.S. Application No. 60/028,489 filed Oct. 15, 1996.\n\n1. Field of the Invention\n\nThis invention relates to a surgical method and analgesic compositions for use in surgery. A composition of the present invention is applied during surgery to reduce pain.\n\n2. Brief Description of Related Art\n\nFollowing surgery, all patients experience some degree of discomfort associated with tissue dissection and removal of tissue during the surgery, at the operative site. Precise mechanisms involved in the production of pain are not fully understood. Pain management is largely composed of systemic administration of narcotics, either orally or parenterally, in the acute and convalescing postoperative state. Systemic administration can be accompanied by side effects, including nausea, vomiting, headache, dizziness, mental disturbance, sedation, constipation, respiratory depression and hypotension. Patient discomfort from pain and side effects of medication can impede patient mobilization, result in longer hospital stays and delay a person's return to normal activities such as employment.\n\nIn lumbar surgery, for example, pain arises from the skin incision, dissection and retraction of paraspinal musculature, removal of bony and ligamentous structures, and from direct trauma to the neural elements. Although the relative contribution of each of these is unknown, and might well vary, it is known that local measures such as local anaesthetic infiltration or epidural block, directed towards all of the mentioned structures can reduce postoperative pain.",
  "cpc": [
    "A61K 9/06",
    "A61K 47/42"
  ],
  "ipc": [
    "A61K 47/42",
    "A61K 9/06"
  ],
  "assignees": [
    "CR Bard Inc"
  ],
  "inventors": [
    "Charles W. Needham",
    "R. John Hurlbert",
    "Nicholas Theodore",
    "Volker K. H. Sonntag"
  ],
  "filing_date": "1997-10-14",
  "publication_date": "2001-07-17",
  "grant_date": "2001-07-17",
  "priority_date": "1996-10-15",
  "application_number": "US-7734098-A",
  "family_id": "21843726",
  "cited_by_count": 113,
  "citations": [
    "US4016877A",
    "US5124155A",
    "US5458631A",
    "US5227165A",
    "US5922340A",
    "US5919473A"
  ]
}