Automation tube positioning methodology

{
  "publication_number": "US9804181B2",
  "country": "US",
  "kind": "B2",
  "title": "Automation tube positioning methodology",
  "abstract": "Methods and systems allow characterization of sample vessels and carriers in an automation system to determine any physical deviation from nominal positions. In response, an offset can be calculated and applied when positioning a carrier relative to a station, such as a testing or processing stations (or vice-versa). This may allow for precise operation of an instrument with a sample vessel on an automation track, while compensating for deviation in manufacturing and other tolerances.",
  "claims": [
    "1. A method for aligning a sample vessel relative to instruments in an automation system in an in-vitro diagnostic (IVD) environment comprising steps of: measuring at least one distance between a reference point in a carrier and a position of a vessel within the carrier; automatically determining, using a processor, an offset between the vessel position and a nominal position based on the at least one distance; moving the carrier to a station within the automation system for interaction between a sample contained in the vessel and the station; and positioning the carrier at a location accessible to the station, the location being chosen to compensate for the offset.",
    "2. The method of claim 1, further comprising aspirating a portion of the sample using a pipette once the carrier has been positioned at the location.",
    "3. The method of claim 1, wherein the step of measuring the at least one distance comprises observing the carrier and vessel with at least one camera.",
    "4. The method of claim 1, wherein the step of measuring the at least one distance comprises observing the carrier and the vessel using an LED and an electro-optical device.",
    "5. The method of claim 1, wherein the steps of measuring and automatically determining an offset are repeated when another vessel is inserted into the carrier.",
    "6. The method of claim 1, further comprising calibrating a line of action of the station.",
    "7. The method of claim 1, wherein a measuring station performs the measuring step and the measuring station is calibrated using a reference carrier prior to performing the measuring step.",
    "8. The method of claim 1, wherein a measuring station performs the measuring step and the measuring station, calibrates the carrier prior to performing the measuring step.",
    "9. A method for aligning a sample vessel relative to instruments in an automation system in an in-vitro diagnostic (IVD) environment comprising steps of: observing a sample vessel carried by a carrier to compare an observed position of the sample vessel to a predetermined nominal position; automatically determining, using a processor, an offset that accounts for the comparison of the observed position and the predetermined nominal position of the vessel; moving the carrier along an automation track to a processing station for interaction between a sample contained in the vessel and the station; and positioning the carrier at a location accessible to the station utilizing the offset such that the sample is placed at a predetermined location relative to the station.",
    "10. The method of claim 9, further comprising aspirating a portion of the sample using a pipette once the carrier has been positioned at the location.",
    "11. The method of claim 9, wherein the step of observing comprises observing the carrier and vessel with at least one camera.",
    "12. The method of claim 9, wherein the step of observing comprises comparing an image of the sample to a pixel mapping of the predetermined nominal position of the vessel in the image.",
    "13. The method of claim 9, wherein the steps of observing and automatically determining an offset are repeated when another vessel is inserted into the carrier.",
    "14. The method of claim 9, wherein the step of observing is performed by a characterization station located on the automation track.",
    "15. The method of claim 9, wherein the step of positioning the carrier comprises positioning the carrier such that the centerline of the vessel is substantially coincident with an arc of movement of a pipette controlled by the station.",
    "16. An automation system for use with a clinical chemistry analyzer comprising: at least one processor; an automation track configured to facilitate moving a plurality of carriers holding samples between a plurality of stations; and a characterization station configured to observe sample vessels in a plurality of carriers on the automation track and communicate observation information to the at least one processor, wherein the at least one processor is configured to determine an offset corresponding to a distance between the centerline of each sample and a nominal position of each corresponding carrier from the information received from the characterization station and facilitate positioning of each corresponding carrier at a stopping position on the automation track, the specific location of the stopping position being determined by the offset such that the centerline of each sample aligns with a predetermined position accessible to one of the plurality of stations in an analyzer.",
    "17. The automation system of claim 16, wherein each carrier is configured to hold each sample vessel substantially vertically by applying a spring force to hold each sample vessel against at least one vertical tine.",
    "18. The automation system of claim 17, wherein each carrier is further configured to utilize a plurality of vertical tines to hold each sample vessel in substantially a transverse center of at least two tines.",
    "19. The automation system of claim 16, wherein the at least one processor is further configured to facilitate stopping each carrier at the stopping position such that the centerline of the vessel is substantially coincident with an arc of movement of a pipette controlled by one of the plurality of the stations.",
    "20. The automation system of claim 16, wherein the characterization station comprises at least one electro-optical device configured to capture an image of each vessel.",
    "21. The automation system of claim 16, wherein the characterization station comprises at least one electro-optical device configured to detect when a sample vessel passes the electro-optical device.",
    "22. The automation system of claim 16, wherein each of the plurality of stations comprises an instrument having a pipette.",
    "23. The automation system of claim 16, wherein at least one of the plurality of stations comprises a sample processing station.",
    "24. A method for aligning a sample vessel in an automation system in an in-vitro diagnostic (IVD) environment comprising steps of: observing a sample vessel carried by a carrier to compare an observed position of the sample vessel to a predetermined nominal position; automatically determining, using a first processor, an offset that accounts for the comparison of the observed position and the predetermined nominal position of the vessel; moving the carrier along an automation track to a processing station for interaction between a sample contained in the vessel and the station; stopping the carrier at a predetermined location at the processing station; and positioning an interaction device of the station at a location relative to the carrier that varies according to the offset determined for the carrier, such that interaction device aligns with the sample vessel.",
    "25. The method of claim 24, wherein the interaction device is a pipette and the method further comprises aspirating a portion of the sample using the pipette once the carrier has stopped.",
    "26. The method of claim 24, wherein the step of observing comprises observing the carrier and vessel with at least one camera.",
    "27. The method of claim 24, wherein the step of observing comprises comparing an image of the sample to a pixel mapping of the expected location of the vessel in the image.",
    "28. The method of claim 24, wherein the steps of observing and automatically determining an offset are repeated when another vessel is inserted into the carrier.",
    "29. The method of claim 24, wherein the step of observing is performed by a characterization station located on the automation track.",
    "30. The method of claim 24, wherein the step of stopping the carrier comprises positioning the carrier such that the centerline of the vessel is substantially coincident with an arc of movement of the interaction device, wherein the interaction device is a pipette.",
    "31. The method of claim 24, wherein the interaction device is a pipette.",
    "32. The method of claim 24, wherein the interaction device is a robot arm.",
    "33. The method of claim 24, wherein the step of positioning the interaction device occurs responsive to the control of a second processor in communication with the first processor.",
    "34. The method of claim 24, wherein the offset includes a lateral component relative to the automation track, and the step of positioning the interaction device includes laterally positioning the interaction device."
  ],
  "description_excerpt": "The present invention relates in general to an automation system for use in a laboratory environment and, more particularly to systems and methods for transporting patient samples for in vitro diagnostics in a clinical analyzer and aligning sample vessels within an analyzer. Embodiments of the present invention are particularly well suited, but in no way limited to, systems and methods for accurately positioning carriers by characterizing them to determine a nominal stopping location.\n\nIn vitro diagnostics (IVD) allows labs to assist in the diagnosis of disease based on assays performed on patient fluid samples. IVD includes various types of analytical tests and assays related to patient diagnosis and therapy that can be performed by analysis of a liquid sample taken from a patient's bodily fluids, or abscesses. These assays are typically conducted with automated clinical chemistry analyzers (analyzers) onto which fluid containers, such as tubes or vials containing patient samples have been loaded. The analyzer extracts a liquid sample from sample vessels and combines the sample with various reagents in special reaction cuvettes or tubes (referred to generally as reaction vessels). In some conventional systems, a modular approach is used for analyzers. A lab automation system can shuttle samples between one sample processing module (module) and another module.",
  "cpc": [
    "G01N 35/021",
    "B65G 43/08",
    "G01N 2035/00326",
    "G01N 2035/00881",
    "G01N 2035/0406",
    "G01N 2035/0462",
    "G01N 2035/0494",
    "G01N 35/00871",
    "G01N 35/0095",
    "G01N 35/0099",
    "G01N 35/04",
    "G01N 35/1011",
    "Y10T 436/113332"
  ],
  "ipc": [
    "B65G 43/08",
    "G01N 35/00",
    "G01N 35/02",
    "G01N 35/04",
    "G01N 35/10"
  ],
  "assignees": [
    "Siemens Healthcare Diagnostics Inc"
  ],
  "inventors": [
    "Ryan German",
    "Benjamin S. Pollack"
  ],
  "filing_date": "2014-01-14",
  "publication_date": "2017-10-31",
  "grant_date": "2017-10-31",
  "priority_date": "2013-01-15",
  "application_number": "US-201414760689-A",
  "family_id": "51210013",
  "cited_by_count": 12,
  "citations": [
    "US3883306A",
    "US4113436A",
    "US4925630A",
    "US5270210A",
    "EP1028320B1",
    "US5939326A",
    "US6072570A",
    "US6878341B2",
    "US20020164808A1",
    "US6937955B2",
    "US7111374B2",
    "US20090193696A1",
    "US20100034701A1",
    "US7457686B2",
    "US20090117620A1",
    "US20090210083A1",
    "US9316659B2",
    "US20150140668A1",
    "US20150241458A1"
  ]
}