Cryogenic cooling positioning apparatus, methods and applications

{
  "publication_number": "US10241015B2",
  "country": "US",
  "kind": "B2",
  "title": "Cryogenic cooling positioning apparatus, methods and applications",
  "abstract": "A method and a cryogenic sample positioning system are provided which include: a sample holder cassette that is vertically coupled to a carousel gear through a first shaft. Each sample holder cassette has a first degree of rotation about the first shaft. A first planet drive gear underlies and is vertically coupled to the carousel gear through a second shaft that extends from the carousel gear through the first planet drive gear. The carousel gear has a second degree of rotation about the second shaft that is different from the first degree of rotation. A planet gear that is laterally connected to a second planet drive gear is interposed between each of the carousel gear and the first planet drive gear. Each of the planet gear and the second planet drive gear selectively define the first degree of rotation, without affecting the second degree of rotation of the carousel gear.",
  "claims": [
    "1. A cryogenic sample positioning system, comprising: at least one sample holder cassette comprising at least one opening, that is vertically coupled to an upper surface of a carousel gear through a first axle shaft, wherein the at least one sample holder cassette has a first degree of rotation about the first axle shaft; a first planet drive gear underlying and vertically coupled to the carousel gear through a second axle shaft that extends from the carousel gear through the first planet drive gear, wherein the carousel gear and the at least one sample holder cassette each have a second degree of rotation about the second axle shaft that is independent of the first degree of rotation; and at least one planet gear that is laterally connected to a second planet drive gear, and is interposed between each of the carousel gear and the first planet drive gear, wherein each of the at least one planet gear and the second planet drive gear selectively define the first degree of rotation, without affecting the second degree of rotation of the carousel gear.",
    "2. The cryogenic sample positioning system of claim 1, wherein the at least one planet gear is vertically coupled to the at least one sample holder cassette through the first axle shaft, wherein the at least one planet gear is isolated from the underlying first planet drive gear.",
    "3. The cryogenic sample positioning system of claim 1, wherein the first and the second planet drive gears are rigidly connected to each other, and are connected to the carousel gear through the second axle shaft, the first and the second planet drive gear being co-axially rotatable about the second axle shaft independent of the rotation of the carousel gear.",
    "4. The cryogenic sample positioning system of claim 1, wherein the at least one planet gear is rotatable by the first planet drive gear through the second planet drive gear, wherein the rotation of each of the first planet drive gear, the at least one planet gear and the second planet drive gear facilitates defining the rotation of the at least one sample holder cassette about the first axle shaft.",
    "5. The cryogenic sample positioning system of claim 1, further comprising a bushing adjoining the second axle shaft, wherein the bushing laterally separates the carousel gear, and the first and the second planet drive gears from the second axle shaft, the bushing comprising a material that has a thermal coefficient of expansion substantially equal to that of stainless steel.",
    "6. The cryogenic sample positioning system of claim 1, further comprising a first pinion gear laterally coupled to the first planet drive gear, and a second pinion gear laterally coupled to the carousel gear, wherein each of the first pinion gear and the second pinion gear are configured to discretely rotate each of the carousel gear and the first planet drive gear.",
    "7. The cryogenic sample positioning system of claim 6, further comprising a first pinion shaft that is attached to the first pinion gear, wherein rotation of the first pinion shaft and the first pinion gear define rotation of the at least one planet gear and the corresponding sample holder cassette of the at least one sample holder cassette about the first axle shaft.",
    "8. The cryogenic sample positioning system of claim 6, further comprising a second pinion shaft that is attached to the second pinion gear, wherein rotation of the second pinion shaft and the second pinion gear define rotation of the carousel gear that is independent of the rotation of the underlying first and the second planet drive gears.",
    "9. The cryogenic sample positioning system of claim 1, wherein the at least one planet gear has a diameter that is less than a diameter of the carousel gear.",
    "10. The cryogenic sample positioning system of claim 1, wherein the cryogenic sample positioning system is enclosed in a cryogenic chamber having an opening, wherein the at least one opening of the at least one sample holder cassette is directly aligned with the opening of the cryogenic chamber so as to accurately position a sample within the at least one opening.",
    "11. A method, comprising: providing a cryogenic sample positioning structure, comprising: at least one sample holder cassette comprising at least one opening that is vertically coupled to an upper surface of a carousel gear through a first axle shaft, wherein the at least one sample holder cassette has a first degree of rotation about the first axle shaft; a first planet drive gear underlying and vertically coupled to the carousel gear through a second axle shaft that extends from the carousel gear through the first planet drive gear, wherein the carousel gear and the at least one sample holder cassette each have a second degree of rotation about the second axle shaft that is independent of the first degree of rotation; and at least one planet gear that is laterally connected to a second planet drive gear, and is interposed between each of the carousel gear and the first planet drive gear, wherein each of the at least one planet gear and the second planet drive gear selectively define the first degree of rotation, without affecting the second degree of rotation of the carousel gear; and disposing the cryogenic sample positioning structure within a cryogenic chamber having an opening, wherein the at least one opening of the at least one sample holder cassette is directly aligned with the opening of the cryogenic chamber so as to accurately position a sample within the at least one opening.",
    "12. The method of claim 11, wherein the step of providing comprises providing the at least one planet gear that is vertically coupled to the at least one sample holder cassette through the first axle shaft, wherein the at least one planet gear is isolated from the first planet drive gear.",
    "13. The method of claim 11, wherein the first and the second planet drive gears are rigidly connected to each other, and are connected to the carousel gear through the second axle shaft, the first and the second planet drive gear being co-axially rotatable about the second axle shaft independent of the rotation of the carousel gear.",
    "14. The method of claim 11, wherein the at least one planet gear is rotatable by the first planet drive gear through the second planet drive gear, wherein the rotation of each of the first planet drive gear, the at least one planet gear, and the second planet drive gear facilitates defining the rotation of the at least one sample holder cassette about the first axle shaft.",
    "15. The method of claim 11, further comprising providing a first pinion gear that is laterally coupled to the first planet drive gear, and a second pinion gear that is laterally coupled to the carousel gear, wherein each of the first pinion gear and the second pinion gear are configured to discretely rotate each of the carousel gear and the first planet drive gear.",
    "16. The method of claim 15, further comprising providing a first pinion shaft that is attached to the first pinion gear, wherein rotation of the first pinion shaft and the first pinion gear define rotation of the at least one planet gear and the corresponding sample holder cassette of the at least one sample holder cassette about the first axle shaft.",
    "17. The method of claim 15, further comprising providing a second pinion shaft that is attached to the second pinion gear, wherein rotation of the second pinion shaft and the second pinion gear define rotation of the carousel gear that is independent of the rotation of the underlying first and the second planet drive gears.",
    "18. The method of claim 11, further comprises providing a bushing adjoining the second axle shaft, wherein the bushing laterally separates the carousel gear, and the first and the second planet drive gears from the second axle shaft, the bushing comprising a material that a thermal expansion of coefficient substantially equal to that of stainless steel.",
    "19. The method of claim 11, wherein the at least one planet gear has a diameter that is less than a diameter of the carousel gear.",
    "20. The method of claim 11, further comprising providing a fiber-optic sensor within the cryogenic chamber, the fiber-optic sensor facilitating determining positioning of the at least one sample holder cassette relative to that of the opening of the cryogenic chamber."
  ],
  "cpc": [
    "G01N 1/42",
    "A01N 1/0242",
    "A01N 1/0257",
    "A01N 1/0268",
    "A01N 1/142",
    "A01N 1/145",
    "A01N 1/147",
    "F16H 1/28",
    "F16H 57/08",
    "F16H 57/12",
    "F25B 19/005",
    "F25D 3/11",
    "G01N 2035/0486",
    "G01N 2223/604",
    "G01N 23/20033",
    "G01N 35/025"
  ],
  "assignees": [
    "MITEGEN LLC"
  ],
  "filing_date": "2017-07-24",
  "publication_date": "2019-03-26",
  "grant_date": "2019-03-26",
  "priority_date": "2016-07-22",
  "application_number": "US-201715657988-A",
  "family_id": "60988374",
  "citations": [
    "US3783736A",
    "US4034643A",
    "US4622457A",
    "US4849176A",
    "US6158196A",
    "US8348720B1",
    "US9193539B2"
  ]
}