CRISPR-associated endonuclease 9

{
  "id": "MLC-T-AGR-001584",
  "term": "CRISPR-associated endonuclease 9",
  "field": "Agriculture and food",
  "definition": "An RNA-guided endodeoxyribonuclease that associates with CRISPR sequences in Streptococcus pyogenes and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small guide RNA (sgRNAs). Structurally, Cas9 consists of an alpha-helix module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand.",
  "synonyms": [
    "Cas9 endonuclease",
    "Cas9 enzyme",
    "Cas9 protein"
  ],
  "subject": "Fields of Study",
  "see_also": [
    "CRISPR-associated endonucleases",
    "CRISPR-Cas systems"
  ],
  "references": [
    "Taken in part from: Medical Subject Headings",
    "NAL Agricultural Thesaurus and Glossary"
  ],
  "translations": {
    "es": "CRISPR proteína asociada 9"
  },
  "url": "https://mlchart.com/terminology/agriculture/crispr-associated-endonuclease-9/"
}