Complement Degradation Process

{
  "id": "MLC-T-ENV-005886",
  "term": "Complement Degradation Process",
  "field": "Environment",
  "definition": "Complement Degradation consists of conjugation, transport, oxidation, and/or proteolysis of complement system proteins; sequentially interacting serum proteins (some serine proteases), their receptors, and related regulatory proteins. Activated by cell-surface bound antibody, immune complexes, or a microbial membrane carbohydrate, complex complement cascades (classical or properdin pathway) generate Membrane Attack Complex, which creates target cell wall pores and lysis. The complement system also plays a role in antibody-dependent cytolysis, anaphylaxis, phagocytosis, opsonization, chemotaxis, and hemolysis.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/environment/complement-degradation-process/"
}