DNA Replication Licensing

{
  "id": "MLC-T-ENV-008353",
  "term": "DNA Replication Licensing",
  "field": "Environment",
  "definition": "A process that limits duplication of the genome to once per cell division cycle. In eukaryotes replication origins are limited to a single initiation event during G1 by temporally separating the assembly of the pre-replication complex (pre-RC) from the initiation of DNA synthesis. An elaborate mechanism regulates the ordered loading of proteins at replication origins which convert a poised, but inactive, minichromosome maintenance (MCM) complex into an enzymatically active helicase.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/environment/dna-replication-licensing/"
}