Extended One-Generation Reproductive Study

{
  "id": "MLC-T-ENV-010520",
  "term": "Extended One-Generation Reproductive Study",
  "field": "Environment",
  "definition": "A redesign of the reproduction toxicity study commonly used to evaluate potential adverse effects of chemical exposure on reproduction and development. This study design constitutes a significant departure from the current guideline studies in that the animals born to treated animals (the F1 generation) would be subjected to a far more comprehensive evaluation than what is currently done (including assessments of the developing immune and nervous systems, when integrated approaches to testing and assessment deem them necessary) and the second generation after the treatment stage (the F2 generation) would not be routinely produced. By selectively producing that second generation and combining elements of the developmental neurotoxicity and immunotoxicity studies, the Extended One Generation Reproductive Toxicity Study will use fewer animals while providing a more in-depth assessment of the reproductive system and the developing organism.",
  "subject": "Chemicals, toxics and pesticides",
  "references": [
    "Toxicity Testing and Risk Assessment Glossary"
  ],
  "url": "https://mlchart.com/terminology/environment/extended-one-generation-reproductive-study/"
}