Chronic Toxicity

{
  "id": "MLC-T-ENV-005001",
  "term": "Chronic Toxicity",
  "field": "Environment",
  "definition": "1. The capacity of a substance to cause long-term poisonous health effects in humans, animals, fish, and other organisms.\n\n2. The capacity of a substance to cause adverse human health effects as a result of chronic exposure.\n\n3. Toxicity impact that lingers or continues for a relatively long period of time, often one-tenth of the life span or longer. Chronic effects could include mortality, reduced growth, or reduced reproduction.\n\n4. The effects of long term or repeated low level exposures to a toxic substance (cancer, liver damage, reproductive disorders, etc.).\n\n5. The potential for a substance to result in adverse effects to an organism after long-term exposure. The chronic toxicity of a compound is established through scientifically verifiable data from animal studies or human exposure tests.\n\n6. Toxic effects from long-term exposure to chemicals; usually nonfatal to organisms. Effects often consist of reduced growth and reproduction, as well as other physiological impacts.\n\n7. The ability of a substance to cause long-term poisonous human health effects.\n\n8. Measure of toxicological responses that result from repeated exposure to a substance over an extended period of time (typically 3 months or longer). Such responses may persist beyond the exposure or may not appear until much later in time than the exposure. HRS measures of chronic toxicity include Reference Dose (RfD) values.\n\n9. Concurrent and delayed adverse effect(s) that occurs only as a result of a chronic exposure.\n\n10. Potential for a substance to result in adverse effects to an organism after long-term exposure. The chronic toxicity of a compound is established through scientifically verifiable data from animal studies or human exposure tests.\n\n11. The capacity of a substance to cause adverse human health effects as a result of chronic exposure. [EPA 2003]\n\n12. The effects of long term or repeated low level exposures to a toxic substance (cancer, liver damage, reproductive disorders, etc.). [EPA 2005e]",
  "subject": "Health and safety",
  "references": [
    "Terms of Env; Terms of Environment",
    "Integrated Risk Information System (IRIS) Glossary; EPA 2003",
    "Sediment Total Maximum Daily Loads (TMDLs) Glossary",
    "Pesticides Glossary; EPA 2005e",
    "PRIA Fee Determination Glossary",
    "Urban Watershed Management Research Terminology",
    "I-BEAM Glossary of Terms",
    "40 CFR Appendix A to Part 300 (CFR 2013)",
    "40 CFR 132.2 (CFR 2013)",
    "Thesaurus of Terms Used in Microbial Risk Assessment"
  ],
  "url": "https://mlchart.com/terminology/environment/chronic-toxicity/"
}