Limit of Detection/Limit of Quantification

{
  "id": "MLC-T-ENV-015783",
  "term": "Limit of Detection/Limit of Quantification",
  "field": "Environment",
  "definition": "The LOD and LOQ concentrations are calculated by applying the compound's calibration curve to the noise response of a sample to obtain a value which is then multiplied by a factor of 3 for LOD (3 times of noise) and 10 for LOQ (10 times of noise). The responses of the analytes are not considered in this approach. Only the noise level is included in the calculation. In some cases, the concentration of the lowest calibration standard is treated as the LOQ. The LOD is not defined in this case, although the LOD is often assumed to be 1/3 of the LOQ. The lowest possible LOD and LOQ values are not critical in these cases. The rationale of this approach is that the expected analyte concentrations in the samples are high and above the lowest calibration concentration and knowledge of the actual LOD/LOA is not necessary. {OPP}",
  "subject": "Policy and guidance",
  "references": [
    "Forum on Environmental Measurements (FEM) Glossary"
  ],
  "url": "https://mlchart.com/terminology/environment/limit-of-detection-limit-of-quantification/"
}