low-dose linear model

{
  "id": "MLC-T-ENV-016110",
  "term": "low-dose linear model",
  "field": "Environment",
  "definition": "A low-dose-linear model is one whose slope is greater than zero at a dose of zero. A low-dose-linear model approximates a straight line only at very low doses; at higher doses near the observed data, a low-dose-linear model can display curvature. The term \"low-dose-linear\" is often abbreviated \"linear,\" although a low-dose-linear model is not linear at all doses. Use of nonlinear approaches does not imply a biological threshold dose below which the response is zero. Estimating thresholds can be problematic; for example, a response that is not statistically significant can be consistent with a small risk that falls below an experiment’s power of detection.",
  "subject": "Health and safety",
  "references": [
    "EPA 2005a"
  ],
  "url": "https://mlchart.com/terminology/environment/low-dose-linear-model/"
}