Non-Linear Dose Response

{
  "id": "MLC-T-ENV-018913",
  "term": "Non-Linear Dose Response",
  "field": "Environment",
  "definition": "1. A pattern of frequency or severity of biological response that does not vary directly with the amount of dose of an agent.\n\n2. The term \"nonlinear\" is used in the Guidelines for Carcinogenic Risk Assessment in a narrower sense than its usual meaning in the field of mathematical modeling. In the cancer guidelines, the term \"nonlinear\" refers to threshold models (which show no response over a range of low doses that include zero) and some nonthreshold models (e.g., a quadratic model, which shows some response at all doses above zero). In the cancer guidelines, a nonlinear model is one whose slope is zero at (and perhaps above) a dose of zero.\n\n3. A pattern of frequency or severity of biological response that does not vary directly with the amount of dose of an agent. [EPA 2003]\n\n4. The term \"nonlinear\" is used in the Guidelines for Carcinogenic Risk Assessment in a narrower sense than its usual meaning in the field of mathematical modeling. In the cancer guidelines, the term \"nonlinear\" refers to threshold models (which show no response over a range of low doses that include zero) and some nonthreshold models (e.g., a quadratic model, which shows some response at all doses above zero). In the cancer guidelines, a nonlinear model is one whose slope is zero at (and perhaps above) a dose of zero. [EPA 2005a]",
  "subject": "Health and safety",
  "references": [
    "Integrated Risk Information System (IRIS) Glossary; EPA 2003",
    "EPA 2005a",
    "Thesaurus of Terms Used in Microbial Risk Assessment"
  ],
  "url": "https://mlchart.com/terminology/environment/non-linear-dose-response/"
}