Benchmark-Dose Approach

{
  "id": "MLC-T-ENV-002971",
  "term": "Benchmark-Dose Approach",
  "field": "Environment",
  "definition": "The benchmark dose (BMD) approach, which involves dose-response modeling to obtain BMDs, i.e., dose levels corresponding to specific response levels near the low end of the observable range of the data, incorporates and conveys more information than the No Observed Adverse Effect Level (NOAEL) or Lowest Observed Adverse Effect Level (LOAEL) process traditionally used for noncancer health effects. The approach is similar to that for determining the POD for cancer endpoints (U.S. EPA 2005a). As the Agency moves toward harmonization of approaches for cancer and noncancer risk assessment, the dichotomy between cancer and noncancer health effects is being replaced by consideration of mode of action and whether the effects of concern are likely to be linear or nonlinear at low doses.",
  "references": [
    "EPA Benchmark Dose Technical Guidance EPA/100/R-12/001 at http://www.epa.gov/raf/publications/pdfs/benchmark_dose_guidance.pdf"
  ],
  "url": "https://mlchart.com/terminology/environment/benchmark-dose-approach/"
}