Point of departure

{
  "id": "MLC-T-ENV-021345",
  "term": "Point of departure",
  "field": "Environment",
  "term_source": "Point of Departure",
  "definition": "1. The dose-response point that marks the beginning of a low-dose extrapolation. This point can be the lower bound on dose for an estimated incidence or a change in response level from a dose-response model (BMD), or a NOAEL or LOAEL for an observed incidence, or change in level of response.\n\n2. A dose that can be considered to be in the range of observed responses, without significant extrapolation. A PoD can be a data point or an estimated point that is derived from observed dose-response data. A PoD is used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures.\n\n3. The point on a dose-response curve established from experimental data, e.g., the benchmark dose, generally corresponding to an estimated low effect level (e.g., 1% to 10% incidence of an effect). Depending on the mode of action and available data, some form of extrapolation below the POD may be employed for low-dose risk assessment or the POD may be divided by a series of uncertainty factors to arrive at a reference dose.\n\n4. A point of departure marks the beginning of extrapolation to lower doses. The POD is an estimated dose (usually expressed in human-equivalent terms) near the lower end of the observed range, without significant extrapolation to lower doses.\n\n5. Point on a dose-response curve established from experimental data, e.g., the benchmark dose, generally corresponding to an estimated low effect level (e.g., 1% to 10% incidence of an effect). Depending on the mode of action and available data, some form of extrapolation below the POD may be employed for low-dose risk assessment or the POD may be divided by a series of uncertainty factors to arrive at a reference dose. Acronym: POD",
  "abbreviation": "PoD",
  "subject": "Science and research",
  "references": [
    "Integrated Risk Information System (IRIS) Glossary; EPA 2003; Thesaurus of Terms Used in Microbial Risk Assessment",
    "Pesticides Glossary",
    "Benchmark Dose Software (BMDS) Glossary of Terms",
    "EPA 2005a; Thesaurus of Terms Used in Microbial Risk Assessment"
  ],
  "url": "https://mlchart.com/terminology/environment/point-of-departure/"
}