Multistage Weibull Model

{
  "id": "MLC-T-ENV-017952",
  "term": "Multistage Weibull Model",
  "field": "Environment",
  "definition": "1. A dose-response model for low-dose extrapolation that includes a term for decreased survival time associated with tumor incidence.\n\n2. A dose-response model for low-dose extrapolation which includes a term for decreased survival time associated with tumor incidence: [See PDF page 144 for formula http://water.epa.gov/scitech/swguidance/standards/upload/2007_10_01_criteria_humanhealth_microbial_thesaurus_microbial-thesaurus.pdf] where: P(d,t)= the probability of a tumor (or other response) from lifetime, continuous exposure at dose d until age t (when tumor is fatal); qᵢ = fitted dose parameters, i=0, 1, . . ., k; k = no greater than the number of dose groups - 1; t₀ = the time between when a potentially fatal tumor becomes observable and when it causes death (t₀³ 1); and z = fitted time parameter (also called \"Weibull\" parameter).",
  "subject": "Health and safety",
  "references": [
    "Integrated Risk Information System (IRIS) Glossary",
    "EPA 2003, EPA 2004"
  ],
  "url": "https://mlchart.com/terminology/environment/multistage-weibull-model/"
}