One Hit Model

{
  "id": "MLC-T-ENV-019554",
  "term": "One Hit Model",
  "field": "Environment",
  "definitions": [
    "A dose-response model based on a mechanistic argument that there is a response after a target site has been hit by a single biologically effective unit of dose within a given time period.",
    "1. Mathematical model based on the biological theory that a single \"hit\" of some minimum critical amount of a carcinogen at a cellular target - namely, DNA - can initiate an irreversible series of events, eventually leading to a tumor.\n\n2. A mathematical model based on the biological theory that a single \"hit\" of some minimum critical amount of a carcinogen at a cellular target such as DNA can start an irreversible series events leading to a tumor.\n\n3. A dose-response model based on a mechanistic argument that there is a response after a target site has been hit by a single biologically effective unit of dose within a given time period. The form of the model, a special case of the gamma, multistage, and Weibull models, is given by: [See PDF page 146 for formula http://water.epa.gov/scitech/swguidance/standards/upload/2007_10_01_criteria_humanhealth_microbial_thesaurus_microbial-thesaurus.pdf] where: P(d) = probability of cancer from lifetime continuous exposure at dose rate d, and λ = fitted dose coefficient.\n\n4. A dose-response model based on a mechanistic argument that there is a response after a target site has been hit by a single biologically effective unit of dose within a given time period. The form of the model, a special case of the gamma, multistage, and Weibull models, is given by:....where: P(d) = probability of cancer from lifetime continuous exposure at dose rate d, and λ = fitted dose coefficient. [EPA 2003]\n\n5. The basic dose-response model based on the concept that a tumor can be induced by a single receptor that has been exposed to a single quantum or effective dose unit of a chemical. [RAIS 2004, SRA 2004]\n\n6. A mathematical model based on the biological theory that a single \"hit\" of some minimum critical amount of a carcinogen at a cellular target such as DNA can start an irreversible series events leading to a tumor. [EPA 2005b]"
  ],
  "subject": [
    "Health and safety",
    "Policy and guidance"
  ],
  "references": [
    "Integrated Risk Information System (IRIS) Glossary",
    "Drinking Water Technical & Legal Terms",
    "Terms of Environment; EPA 2005b",
    "EPA 2003",
    "Adapted from Thesaurus of Terms Used in Microbial Risk Assessment",
    "Thesaurus of Terms Used in Microbial Risk Assessment"
  ],
  "url": "https://mlchart.com/terminology/environment/one-hit-model/"
}