One-hit model

{
  "id": "MLC-T-CHM-008237",
  "term": "One-hit model",
  "field": "Chemistry",
  "definition": "A mathematical model used in toxicology to describe the dose-response relationship for certain biological effects, particularly carcinogenesis. It postulates that a single molecular event or \"hit\" by a toxicant is sufficient to initiate the adverse effect. This model often assumes a linear relationship between dose and response at low doses, without a threshold.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1275 (https://doi.org/10.1351/pac200779071153)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/one-hit-model/"
}