Hit threshold

{
  "id": "MLC-T-CHM-005323",
  "term": "Hit threshold",
  "field": "Chemistry",
  "definition": "A predefined statistical or biological cutoff value used to distinguish active compounds (hits) from inactive ones in a screening assay. Compounds exhibiting activity beyond this threshold are considered potential candidates for further investigation. This threshold is often determined based on the assay's variability and desired stringency.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "active",
    "primary screen"
  ],
  "references": [
    "PAC, 2011, 83, 1129. 'Glossary of terms used in biomolecular screening (IUPAC Recommendations 2011)' on page 1143 (https://doi.org/10.1351/PAC-REC-09-05-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/hit-threshold/"
}