Confirmed hit

{
  "id": "MLC-T-CHM-002411",
  "term": "Confirmed hit",
  "field": "Chemistry",
  "definition": "A compound or substance identified in an initial high-throughput screening as having a desired biological activity, which is then re-tested and validated in a secondary assay. This re-testing confirms the activity and often eliminates false positives from the primary screen. A confirmed hit serves as a starting point for further drug discovery efforts.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2011, 83, 1129. 'Glossary of terms used in biomolecular screening (IUPAC Recommendations 2011)' on page 1136 (https://doi.org/10.1351/PAC-REC-09-05-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/confirmed-hit/"
}