Hit expansion

{
  "id": "MLC-T-CHM-005321",
  "term": "Hit expansion",
  "field": "Chemistry",
  "definition": "The process of synthesizing and testing a series of structurally related compounds around an initial 'hit' molecule identified in a high-throughput screen. This aims to explore the structure-activity relationship (SAR) and identify more potent or selective compounds. It often involves modifying the chemical scaffold of the original hit.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "hit",
    "scaffold"
  ],
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1737 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/hit-expansion/"
}