Analogue

{
  "id": "MLC-T-CHM-000541",
  "term": "Analogue",
  "field": "Chemistry",
  "definition": "A chemical compound that is structurally similar to another but differs by a certain component, such as the variation of an atom, functional group, or substructure. In medicinal chemistry, analogues of a lead compound are synthesized and tested to explore the structure-activity relationship (SAR) and find a molecule with a more favorable biological or pharmacokinetic profile. A bioisostere is a type of analogue where substituents or groups with similar physical or chemical properties are interchanged.",
  "synonyms": [
    "analog"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "ADMET",
    "analogue-based drug discovery",
    "follow-on drug"
  ],
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1727 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/analogue/"
}