Bioisostere

{
  "id": "MLC-T-CHM-001274",
  "term": "Bioisostere",
  "field": "Chemistry",
  "definition": "A chemical substituent or group that has similar physical or chemical properties to another and produces broadly similar biological effects. Bioisosteres are used in medicinal chemistry to modify a lead compound's properties, such as potency, selectivity, or metabolic stability, while retaining its desired biological activity. Common bioisosteric replacements include hydroxyl for thiol or carboxyl for sulfonyl.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 1998, 70, 1129. 'Glossary of terms used in medicinal chemistry (IUPAC Recommendations 1998)' on page 1129 (https://doi.org/10.1351/pac199870051129)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/bioisostere/"
}