Analogue-based drug discovery

{
  "id": "MLC-T-CHM-012868",
  "term": "Analogue-based drug discovery",
  "field": "Chemistry",
  "definition": "A strategy in medicinal chemistry where new drug candidates are developed by chemically modifying existing drugs or natural products. This approach involves making small structural changes to a known active compound to improve its efficacy, reduce side effects, or enhance pharmacokinetic properties. It is a common method for generating \"me-too\" drugs.",
  "synonyms": [
    "analog-based drug discovery"
  ],
  "subject": "Chemistry and Human Health",
  "see_also": [
    "me-too drug",
    "ligand-based drug design"
  ],
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1727 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/analogue-based-drug-discovery/"
}