Transition state analogue

{
  "id": "MLC-T-CHM-012239",
  "term": "Transition state analogue",
  "field": "Chemistry",
  "definition": "A stable compound that structurally resembles the transition state of a chemical reaction. These molecules bind more tightly to enzymes than the natural substrate, effectively inhibiting the enzyme's activity. This strong binding occurs because the enzyme has evolved to stabilize the transition state, and the analogue mimics this high-energy intermediate.",
  "subject": "Organic and Biomolecular Chemistry",
  "see_also": [
    "transition state"
  ],
  "references": [
    "PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1174 (https://doi.org/10.1351/pac199466051077)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/transition-state-analogue/"
}