Prodrug conjugate

{
  "id": "MLC-T-CHM-009502",
  "term": "Prodrug conjugate",
  "field": "Chemistry",
  "definition": "A macromolecular construct where a prodrug is covalently linked to a polymer or another substrate. This conjugation aims to enhance the therapeutic efficacy, reduce side effects, or improve the pharmacokinetic profile of the drug. The linkage is designed to be cleavable under specific physiological conditions, releasing the active drug.",
  "subject": "Polymer",
  "see_also": [
    "conjugate"
  ],
  "references": [
    "PAC, 2022, 94, 559. 'Terminology and the naming of conjugates based on polymers or other substrates (IUPAC Recommendations 2021)' on page 563 (https://doi.org/10.1515/pac-2020-0502)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/prodrug-conjugate/"
}