Fragment-based lead discovery

{
  "id": "MLC-T-CHM-004641",
  "term": "Fragment-based lead discovery",
  "field": "Chemistry",
  "definition": "A drug discovery approach that identifies small molecular fragments that bind to a biological target, which are then grown or linked to create higher-affinity lead compounds. This method relies on detecting weak binding events using biophysical techniques such as NMR or X-ray crystallography. It offers an efficient way to explore chemical space and develop novel drug candidates.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "fragment",
    "hit",
    "lead"
  ],
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1735 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/fragment-based-lead-discovery/"
}