Frame-shift mutation

{
  "id": "MLC-T-CHM-004642",
  "term": "Frame-shift mutation",
  "field": "Chemistry",
  "definition": "A type of gene mutation caused by the insertion or deletion of a number of nucleotides not divisible by three in a DNA sequence. This alteration shifts the reading frame of the codons during protein synthesis, leading to a completely different amino acid sequence downstream from the mutation. Such mutations often result in non-functional proteins due to premature stop codons.",
  "subject": "Chemistry and the Environment",
  "see_also": [
    "gene",
    "insertion",
    "mutation",
    "nucleotides",
    "reading"
  ],
  "references": [
    "PAC, 1992, 64, 143. 'Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)' on page 154 (https://doi.org/10.1351/pac199264010143)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/frame-shift-mutation/"
}