Knockout mutation

{
  "id": "MLC-T-CHM-006375",
  "term": "Knockout mutation",
  "field": "Chemistry",
  "definition": "A genetic alteration that results in the complete inactivation or deletion of a specific gene, preventing the production of its functional protein product. This type of mutation is often intentionally introduced in laboratory organisms to study gene function. It leads to a loss-of-function phenotype for the affected gene.",
  "synonyms": [
    "null mutation"
  ],
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 771 (https://doi.org/10.1515/pac-2015-1202)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/knockout-mutation/"
}