Framework region

{
  "id": "MLC-T-CHM-004643",
  "term": "Framework region",
  "field": "Chemistry",
  "definition": "Relatively conserved segments of amino acids within the variable regions of antibody and T-cell receptor chains, which provide the structural scaffold for the hypervariable complementarity-determining regions (CDRs). These regions maintain the overall three-dimensional structure of the antigen-binding site. There are typically four framework regions (FR1-FR4) in each variable domain.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "T-cell receptor",
    "hypervariable region",
    "variable region"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1167 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/framework-region/"
}