Fv fragment

{
  "id": "MLC-T-CHM-004734",
  "term": "Fv fragment",
  "field": "Chemistry",
  "definition": "The smallest antigen-binding unit of an antibody, consisting of the variable regions of both the heavy and light chains, held together by non-covalent interactions or a disulfide bond. This fragment retains the full antigen-binding specificity and affinity of the parent antibody. Single-chain Fv (scFv) fragments, where the variable regions are linked by a flexible peptide, are widely used in biotechnology and therapeutics.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "variable region",
    "heavy chain",
    "light chain"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1165 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/fv-fragment/"
}