Back-mutation

{
  "id": "MLC-T-CHM-001080",
  "term": "Back-mutation",
  "field": "Chemistry",
  "definition": "A genetic mutation that restores the original wild-type sequence or phenotype that was lost due to an earlier forward mutation. This reversal can occur through a true back-mutation, where the exact original nucleotide sequence is restored, or through a suppressor mutation at a different site that compensates for the original mutation. Back-mutations are often studied in microbial genetics to understand mutation rates and mechanisms.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1173 (https://doi.org/10.1351/pac200779071153)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/back-mutation/"
}