Hit

{
  "id": "MLC-T-CHM-005320",
  "term": "Hit",
  "field": "Chemistry",
  "definition": "A compound that demonstrates a predefined level of activity in a screening assay during a drug discovery campaign. This initial finding serves as a promising starting point for further investigation and chemical modification. A confirmed hit is a compound whose activity is reproduced upon retesting and is then advanced to the lead generation phase.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1737 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/hit/"
}