Fragment

{
  "id": "MLC-T-CHM-004636",
  "term": "Fragment",
  "field": "Chemistry",
  "definition": "A small molecule, typically with a molecular weight below 300 Daltons, used in fragment-based drug discovery. These low-complexity compounds are screened for weak binding to a biological target, such as a protein. Identified fragments that bind serve as starting points for building more potent and selective lead compounds through chemical modification or by linking multiple fragments together.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1735 (https://doi.org/10.1351/PAC-REC-12-11-23)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/fragment/"
}