Counter-screen

{
  "id": "MLC-T-CHM-002642",
  "term": "Counter-screen",
  "field": "Chemistry",
  "definition": "A secondary assay performed in biomolecular screening to distinguish true positive hits from false positives or compounds with undesirable activity. This follow-up screen tests the active compounds from a primary screen against a different but related target or in a modified assay format. For example, a counter-screen can identify compounds that interfere with the detection technology itself rather than interacting with the biological target.",
  "subject": "Chemistry and Human Health",
  "references": [
    "PAC, 2011, 83, 1129. 'Glossary of terms used in biomolecular screening (IUPAC Recommendations 2011)' on page 1136 (https://doi.org/10.1351/PAC-REC-09-05-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/counter-screen/"
}