Counter-regulation hypothesis

{
  "id": "MLC-T-CHM-002641",
  "term": "Counter-regulation hypothesis",
  "field": "Chemistry",
  "definition": "A hypothesis within the hygiene hypothesis proposing that repeated infections in early childhood protect against atopy by inducing regulatory cytokines, such as interleukin-10 and transforming growth factor beta, that suppress both T helper 1 and T helper 2 responses. It was put forward as an alternative to the Th1/Th2 imbalance model, in which infections shift immune responses toward Th1 and away from Th2, the arm linked to allergic disease.",
  "subject": "Chemistry and Human Health",
  "see_also": [
    "Th1 cell",
    "Th2 cell",
    "atopy",
    "cytokine",
    "interleukin",
    "transforming growth factor β"
  ],
  "references": [
    "PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1150 (https://doi.org/10.1351/PAC-REC-11-06-03)"
  ],
  "url": "https://mlchart.com/terminology/chemistry/counter-regulation-hypothesis/"
}