Benchmark Response

{
  "id": "MLC-T-ENV-002969",
  "term": "Benchmark Response",
  "field": "Environment",
  "definition": "1. An adverse effect, used to define a benchmark dose from which an RfD (or RfC) can be developed. The change in response rate over background of the BMR is usually in the range of 5-10%, which is the limit of responses typically observed in well-conducted animal experiments.\n\n2. A designated level or percent of response relative to the control level of response used in calculating a BMD.\n\n3. The response, generally expressed as in excess of background (see for example, Extra Risk), at which a benchmark dose or concentration is desired (see Benchmark Dose, Benchmark Concentration).\n\n4. A predetermined level of altered response or risk at which the benchmark dose is calculated.\n\n5. An adverse effect, used to define a benchmark dose from which an RfD (or RfC) can be developed. The change in response rate over background of the BMR is usually in the range of 5-10%, which is the limit of responses typically observed in well-conducted animal experiments. [EPA 2003]\n\n6. Response, generally expressed as in excess of background (see for example, Extra Risk), at which a benchmark dose or concentration is desired (see Benchmark Dose, Benchmark Concentration).\n\n7. A predetermined change in the response rate of an adverse effect relative to the background response rate of this effect. The BMR is the basis for deriving BMDs and BMDLs. See Benchmark Dose Technical Guidance (EPA, 2012).",
  "abbreviation": "BMR",
  "subject": "Science and research",
  "references": [
    "Integrated Risk Information System (IRIS) Glossary; Risk Assessment Glossary; EPA 2003",
    "Pesticides Glossary",
    "Benchmark Dose Software (BMDS) Glossary of Terms",
    "EPA Framework for Cumulative Risk Assessment Glossary EPA/630/P-02/001F May 2003 EPA Risk Assessment Forum at oaspub.epa.gov/eims",
    "Thesaurus of Terms Used in Microbial Risk Assessment",
    "Health Effects Notebook Glossary"
  ],
  "url": "https://mlchart.com/terminology/environment/benchmark-response/"
}