MLchartDataset catalogue

Multidrug resistance process

Term · Environment · MLC-T-ENV-017899

Simultaneous resistance to a spectrum of unrelated drugs following exposure to a single agent. Mechanisms involve expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, decreased topoisomerase II activity, and changes in various cellular proteins.

Table 1. Record
IdentifierMLC-T-ENV-017899
FieldEnvironment
SubjectBiological substances
ReferencesNational Cancer Institute Glossary
Record as JSON 
{
  "id": "MLC-T-ENV-017899",
  "term": "Multidrug resistance process",
  "field": "Environment",
  "term_source": "Multidrug Resistance Process",
  "definition": "Simultaneous resistance to a spectrum of unrelated drugs following exposure to a single agent. Mechanisms involve expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, decreased topoisomerase II activity, and changes in various cellular proteins.",
  "subject": "Biological substances",
  "references": [
    "National Cancer Institute Glossary"
  ],
  "url": "https://mlchart.com/terminology/environment/multidrug-resistance-process/"
}

Record 17,424 of 29,894 in Environment terminology (MLC-0121). Request the full dataset.