T-cell differentiation in thymus

{
  "id": "MLC-T-ENV-027697",
  "term": "T-cell differentiation in thymus",
  "field": "Environment",
  "term_source": "T-Cell Differentiation in Thymus",
  "definition": "Progression of T cell precursors in the thymus through many stages of maturation. These stages include regulated expression of the alpha and beta (or gamma and delta) chains of the T cell receptor, expression of both CD4 and CD8 molecules (double positive stage), down regulation to a single positive stage (CD4 or CD8), as well as allowing those thymocytes to die which are unable to bind to self MHC molecules (death by neglect), selecting those thymocytes with T Cell Receptors that are able to bind to self MHC molecules with moderate affinity (positive selection), and deleting those thymocytes having T Cell Receptors that bind with high affinity to self MHC (negative selection), before allowing mature T cells to emigrate to the periphery.",
  "subject": "Biological substances",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/environment/t-cell-differentiation-in-thymus/"
}