acetylglucosaminyltransferase V inhibitor PhOx430

{
  "id": "MLC-T-ONC-009604",
  "term": "acetylglucosaminyltransferase V inhibitor PhOx430",
  "field": "Oncology and biomedicine",
  "definition": "An inhibitor of the glycosyltransferase N-Acetylglucosaminyltransferase V (GnT-V), with potential antineoplastic activity. Upon administration, GnT-V inhibitor PhOx430 targets, binds to and inhibits the activity of GnT-V, a glycosylation enzyme that synthesizes the beta1, 6-GlcNAc branch in N-glycans. This inhibits the glycosylation of tumor cells and downregulates cell surface receptors implicated in tumor cell growth and metastasis. GnT-V and its product N-glycans, upregulated in various types of cancer cells, are associated with cancer proliferation and metastasis.",
  "synonyms": [
    "N-acetylglucosaminyltransferase V inhibitor PhOx430",
    "GnT-V inhibitor PhOx430"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/acetylglucosaminyltransferase-v-inhibitor-phox430/"
}