Akeega

{
  "id": "MLC-T-ONC-000347",
  "term": "Akeega",
  "field": "Oncology and biomedicine",
  "definition": "A combination of niraparib tosylate monohydrate and abiraterone acetate used with prednisone to treat adults with prostate cancer that has spread to other parts of the body and is castration resistant (has not responded to treatments that lower testosterone levels). It is used in patients who have a certain type of abnormal BRCA gene. Niraparib tosylate monohydrate blocks an enzyme involved in many cell functions, including the repair of DNA damage. Blocking this enzyme may help keep cancer cells from repairing their damaged DNA, causing them to die. Abiraterone acetate lowers the amount of androgens (male hormones), such as testosterone, made by the body. This may stop the growth of cancer cells that need androgens to grow. The combination of niraparib tosylate monohydrate and abiraterone acetate may work better than either drug alone. Akeega is a type of PARP inhibitor and a type of antiandrogen. Also called niraparib tosylate monohydrate and abiraterone acetate.",
  "synonyms": [
    "niraparib tosylate monohydrate and abiraterone acetate"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms"
  ],
  "url": "https://mlchart.com/terminology/oncology/akeega/"
}