niraparib tosylate monohydrate and abiraterone acetate

{
  "id": "MLC-T-ONC-005844",
  "term": "niraparib tosylate monohydrate and abiraterone acetate",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A combination of two drugs used with prednisone to treat adults with prostate cancer that has spread to other parts of the body and is castration resistant (has not responded to treatments that lower testosterone levels). It is used in patients who have a certain type of abnormal BRCA gene. Niraparib tosylate monohydrate blocks an enzyme involved in many cell functions, including the repair of DNA damage. Blocking this enzyme may help keep cancer cells from repairing their damaged DNA, causing them to die. Abiraterone acetate lowers the amount of androgens (male hormones), such as testosterone, made by the body. This may stop the growth of cancer cells that need androgens to grow. The combination of niraparib tosylate monohydrate and abiraterone acetate may work better than either drug alone. Niraparib tosylate monohydrate and abiraterone acetate is a type of PARP inhibitor and a type of antiandrogen. Also called Akeega.",
    "An orally bioavailable fixed dose combination agent containing the acetate ester prodrug of the steroidal compound abiraterone, an inhibitor of the cytochrome p450 (CYP) family member 17 alpha-hydroxylase/C17,20-lyase (CYP17; CYP17A1), and the tosylate monohydrate salt form of niraparib, an inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with anti-androgen and antineoplastic activities. Upon administration of niraparib tosylate monohydrate and abiraterone acetate, abiraterone acetate is converted to its active form abiraterone, which, in turn, targets, binds to and inhibits the enzymatic activity of CYP17, thereby preventing the formation of steroid intermediates and androgens involved in androgen synthesis. This suppresses testosterone production by testes, adrenals and testosterone-dependent prostate tumor cells in order to decrease testosterone to castrate-range levels, which inhibits proliferation of testosterone-dependent cancer cells. In addition, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, and promoting genomic instability, which results in cancer cell apoptosis. PARP family proteins are often overexpressed in cancer cells and are activated by single-strand DNA (ssDNA) breaks to catalyze post-translational ADP-ribosylation of nuclear proteins, which promotes DNA repair and cancer cell survival."
  ],
  "synonyms": [
    "Akeega",
    "abiraterone acetate/niraparib tosylate monohydrate",
    "niraparib/abiraterone acetate",
    "abiraterone acetate and niraparib tosylate monohydrate",
    "niraparib and abiraterone acetate",
    "abiraterone acetate/niraparib",
    "niraparib tosylate monohydrate/abiraterone acetate"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/niraparib-tosylate-monohydrate-and-abiraterone-acetate/"
}